Dosage* Pregnancy category: Pyridoxine (Vitamin B 6)† 25 mg orally three times daily: A‡ Doxylamine (Unisom)† 25 mg orally once daily § Antiemetics:
An estimated 60% of cases resolve by the end of the first trimester, and 87% resolve by 20 weeks' gestation
Last Update: September 4, 2023
The appropriate dose of Metoclopramide during pregnancy is 10 mg and it’s administered orally, intramuscularly, or intravenously, before each meal
10 mg every 6–8 hours
Category A may appear reassuring in terms of safety, but does not give any indication of the drug's efficacy
Metoclopramide can be used to control nausea in any situation (except in the event of stomach bleeding or intestinal obstruction)
Dosing interval: ≥6 hours
Metoclopramide should only be used after careful examination to avoid masking an underlying disorder, e
After oral and intranasal administration, most infants would receive less than 10% of the maternal weight-adjusted dosage, but some receive doses that achieve pharmacologically active serum levels, elevated serum prolactin and possible gastrointestinal side effects
Includes Metoclopramide indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more
Pregnancy Category B
Use of metoclopramide is contra-indicated in children aged under 1 year; Metoclopramide should only be prescribed for short-term use (up to 5 days); Recommended dose is 100–150 micrograms/kg (max
If you are pregnant, chances are that you will experience vomiting and nausea
Concomitant use w/ other centrally-acting drugs, drugs prolonging QT interval
5mg/kg body weight
Morning sickness is a classic symptom of early pregnancy, often unpleasant but mild and clearing up on its own by the end of the first trimester
v
Diet – drinking little and often, small meals high in carbohydrate and low fat, avoid triggering foods Metoclopramide may be used short-term for the treatment of gastrointestinal reflux disease that is unresponsive to other medications or to treat diabetic stasis
Tell your doctor if you are pregnant before taking metoclopramide
1 Antiemetics used in pregnancy include; metoclopramide, prochlorperazine cyclizine, promethazine and ondansetron
Follow the dosage directions on the label and take this medication 30 minutes before eating
It has been widely used for pregnancy sickness in the US and Canada and studies have shown no link with birth defects in the baby