COMMON BRAND NAME (S): Wellbutrin
Maximum dose: 400 mg/day; maximum single dose should not exceed 200 mg
Bupropion HCl sustained-release (Wellbutrin SR): The typical starting dose is 150 mg by mouth once daily in the morning
Wellbutrin (bupropion) and Lexapro (escitalopram) are antidepressant medications
Objectives: Review the FDA-approved on-label indications of bupropion, as well as other off-label uses
Atypical antidepressants change the levels of one or more neurotransmitters, such as dopamine, serotonin or norepinephrine
Bupropion does not affect the reuptake of serotonin or inhibit monoamine oxidase
How it works Expiration Drug Images What is Wellbutrin? Wellbutrin is a brand-name prescription drug
Serotonin modulators, such as trazodone, and dopamine-norepinephrine reuptake inhibitors, such as bupropion, also increase synaptic serotonin availability
Most patients without worsening symptoms can receive outpatient
Serotonin syndrome most often occurs when two medications that raise the level of serotonin are combined
fast or irregular heartbeats; or
Wellbutrin is considered an atypical antidepressant because instead of increasing serotonin levels in the brain, it
It is important to be aware of the potential for serotonin syndrome What to Know About Adderall, Wellbutrin, and Serotonin Syndrome
Melatonin natural health products and supplements: Presence of serotonin and significant variability of melatonin content
(2016)
Patients present with a combination of neuromuscular, autonomic, and mental status symptoms
3 Increased catecholamine
Data sources: MEDLINE (1966-September 1999), Embase (1980-August 1999), PsyclNFO (1887-August 1999), International Pharmaceutical Abstracts (1970-August 1999), and CIANHL databases were searched
duloxetine (Cymbalta) 12 hours
MHRA/CHM advice: Bupropion (Zyban®): risk of serotonin syndrome with use with other serotonergic drugs (November 2020)Cases of serotonin syndrome have been reported in patients taking bupropion with other serotonergic drugs, such as selective serotonin re-uptake inhibitors (SSRIs) and serotonin and noradrenaline re-uptake inhibitors (SNRIs);
Bupropion: a systematic review and meta-analysis of effectiveness as an antidepressant
Serotonin is a chemical messenger associated with mood, memory, and many other behaviors
Serotonin syndrome in a patient on tramadol, bupropion, trazodone, and oxycodone
psym
Authors Brian A Falls 1 Serotonin syndrome symptoms include agitation, blood pressure change, fever, rapid heart rate, seizures and twitching muscles