Our
Here we show that Cdk5-depleted (Cdk5-shRNA) HeLa cells show higher sensitivity to S-phase irradiation, chronic hydroxyurea exposure, and 5-fluorouracil and 6-thioguanine
In addition to being a member of the RPA board of directors, he’s been a life member of Kappa Alpha Psi since 1993
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It also recruits specific H3-H4 chaperones, which facilitate the assembly of new nucleosomes
The exchange of RPA with RAD51 on ssDNA is enhanced by the BRCA2-associated factor DSS1, which is a small, highly acidic protein that weakens the grip of RPA on ssDNA 130
Hydroxyurea oral capsule is available as the brand-name drugs Hydrea and Droxia Here, we show that hyperphosphorylated RPA2 associates with ssDNA and recombinase protein Rad51 in response to replication arrest by hydroxyurea (HU) treatment
Common side effects include bone marrow
muscle spasms (tetany) or twitching seizures
Dispense in a
Sickle cell anemia (SCA) is a severe, inherited hemoglobin disorder affecting 100,000 persons in the US and millions worldwide
Generic Name Hydroxyurea DrugBank Accession Number DB01005 Background
Canadian Brand Name
The fork protection complex prevents premature replisome stalling and/or premature disassembly upon stress
muscle spasms (tetany) or twitching seizures
492-502
Conversely, in cells treated with hydroxyurea (HU), UNG2 was recruited to stalled replication forks by binding to RPA
This study not only discovers a W-RPA mechanism but also provides a novel phototherapy strategy for