Action of drug fluconazole

Demi lopes trios
  • This enzyme functions to convert lanosterol to ergosterol
  • Oropharyngeal and esophageal candidiasis
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  • Therapeutic Action
  • Diflucan IV; Diflucan; Descriptions
  • The high safety profile of triazoles, in particular fluconazole (Fig
  • It is in the antimetabolite, antifungal class of drugs
  • Distribution to vaginal tissue produces concentrations 2
  • Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness

    Fluconazole interacts with 14-demethylase, a cytochrome P-450 enzyme responsible for

    Fluconazole is used to treat fungal infections, including yeast infections of the vagina, mouth, throat, esophagus (tube leading from the mouth to the stomach), abdomen

    It will not prevent or treat colds, the

    Find information on Fluconazole (Diflucan) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration

    Then the pharmacodynamics of each major antifungal drug class (polyenes, flucytosine, azoles, and echinocandins) is discussed

    Candida spp

    C

    Fluconazole is designated chemically as 2,4-difluoro-α,α 1 -bis (1H-1,2,4-triazol-1-ylmethyl) benzyl alcohol with an empirical formula of C 13 H 12 F 2 N 6 O and

    A

    Mechanism of Action: Fluconazole is a triazole derivative antifungal agent that inhibits the CYP450-mediated 14-α-lanosterol demethylation in susceptible fungi

    https Fluconazole can be the alternative drug but it can cause liver and/or renal toxicity

    Fluconazole is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida

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    If you are 65 or older, use this medicine (fluconazole tablets) with care

    2

    Your doctor will measure blood levels of phenytoin while you’re taking fluconazole Drug Name Generic Name : fluconazole Brand Name: Diflucan Classification: Antifungal Pregnancy Category C Dosage & Route Available forms : Tablets—50, 100, 150, 200 mg; powder for oral suspension—10, 40 mg/mL; injection—2 mg/mL Dosages : Individualize dosage; same for oral or IV routes because of rapid and almost complete absorption

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    Fluconazole is a highly selective inhibitor of fungal cytochrome P450 dependent enzyme lanosterol 14-α-demethylase

    4

    Fungal cell membranes have a unique sterol, ergosterol, which replaces cholesterol found in mammalian cell membranes

    Fluconazole is a synthetic triazole antifungal drug with a broader spectrum of action than that of imidazoles

    First, eight molecules of amphotericin B interact with eight ergosterol molecules and form channels

    Fluconazole-Drug Information Portal [Internet]

    However, the prolonged use of fluconazole (FLC) along with other antifungal drugs (polyenes and echinocandins) results in drug resistance by a phenomenon of Multi drug resistance

    A bioavailablity of 76% has been reported for ketoconazole

    , 2010b; Patil et al

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