Erythromycin dirithromycin pharmacokinetics

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  • Dirithromycin has unique pharmacokinetics which distinguish it
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  • The human pharmacokinetics and clinical pharmacology of
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  • Erythromycin pharmacokinetics in man J Int Med Res
  • The unbound fraction (fu) of erythromycin was s
  • Azithromycin is an azalide antimicrobial agent
  • It is hoped that the data outlined in this paper will prove a useful baseline for future studies with erythromycin lactobionate in healthy volunteers and patients with Dirithromycin is a new macrolide that has a 14-member lactone ring and that is chemically related to erythromycylamine

    Steady-state peak serum concentrations are 1

    The bioavailability of a 500 mg oral dose of azithromycin is only about 37%, and peak serum concentration attained is 0

    Serum AAG levels were 4

    The human pharmacokinetics and clinical pharmacology of dirithromycin have been studied

    Erythromycin may also directly inhibit the conversion of carbamazepine to its epoxide

    Methods: The effects of grapefruit juice intake on the pharmacokinetics of erythromycin were investigated in six healthy male volunteers, who received 400 mg erythromycin with either water or grapefruit juice

    Both radioactivity and bioactivity

    or 500 mg dirithromycin qd for 5 days (wash out period, 35 The pharmacokinetics of two orally administered macrolides, spiramycin and erythromycin, were compared in six healthy male volunteers in a single dose cross-over study

    Since erythromycin is a bacteriostatic antibiotic, it inhibits bacterial growth rather than eradicating it

    Objective: To determine the pharmacokinetics of erythromycin stinoprate capsules and to provide guidance for clinical research

    The results showed that erythromycin ethylsuccinate was better than erythromycin stearate for oral treatment in that it was rapidly and

    Erythromycin is destroyed at acid pH and is therefore given orally as an enteric-coated tablet or an acid-stable pro-drug (erythromycin ethyl succinate); it can also be administered intravenously

    8 6 8

    The pharmacokinetic pattern of erythromycin propionate-N-acetylcysteinate (EPAC) (erythromycin stinoprate I

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