Duloxetine and liver

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  • 8 % of duloxetine initiators and 4
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  • Chronic liver dysfunction or cirrhosis: Not recommended
  • The drug can cause fatty liver disease and liver injury
  • The study by Xue et al
  • Safety and efficacy have not been established for other indications
  • Pitolisant: CYP2D6 Inhibitors (Moderate) may
  • The U
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  • Read the latest news and reviews about the drug as well as potential side effects and popular alternatives

    If coadministered with strong or moderate CYP2D6 inhibitors, reduce eliglustat dose from 84 mg BID to 84 mg once daily in extensive and intermediate metabolizers; eliglustat is contraindiated if strong or moderate CYP2D6

    The most commonly reported side effects included nausea, somnolence, headache, and dizziness

    Label,7 Biliary secretion is thought to play a role due to timeline of fecal excretion exceeding the

    anxiety – the starting dose is 30mg, taken once a Find everything you need to know about Cymbalta (duloxetine), including what it is used for, warnings, reviews, side effects, and interactions

    Key facts

    Common side effects

    People with depression have a consistently low mood and other symptoms

    Drug-induced liver injury (DILI) is a rare entity with an incidence rate of 19 per 100,000 treated individuals []

    These should improve over time as your body gets used to the medication

    fluvoxamine , and quinidine increase blood levels of duloxetine by reducing its metabolism in the liver

    Do not use

    In this propensity score-matched cohort analysis in a US commercially insured population (01 August 2004 to 31 December 2010), we compared individuals with depression and

    Azor

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