In most patients, the drug is well tolerated, however, about 2% of treated patients develop a skin rash
Prevention Preventative measures include using alternative drugs, genetic screening, and modifying the starting dose
The use of allopurinol only for accepted indications and in dosages adjusted for a patient's renal function may be the only means
Allopurinol is generally recommended as a first-line urate-lowering therapy in the management of gout