Increased risk for cardiac ischemic events during short- and long-term follow-up in clopidogrel-treated patients with high on-treatment platelet reactivity has been
We conclude that when performing TEG to predict clinical efficacy, residual platelet reactivity has superiority over platelet inhibition rate as a measure of thrombotic
TEG allows evaluation of platelet function, whereas traditional coagulation laboratories merely monitor the platelet count
Keywords: clopidogrel, HPLC, platelet function assays, pharmacogenetic assays
; Ajello, V
Effects of thrombelastogram-guided (TEG-guided) clopidogrel and aspirin on major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) were
The TEG ® Platelet Mapping™ assay (Haemoscope Corporation, Niles, Illinois, US) relies on evaluation of clot strength to enable a quantitative analysis of
6%) of platelet transfusion therapy due to increased chest tube drainage
; Colella, D
In a multivariable analysis, only the third tertile remained little or no urination; a seizure; low blood sugar - headache, hunger, sweating, irritability, dizziness, fast heart rate, and feeling anxious or shaky; or
0026); the rate of clopidogrel-resistant patients was 9% at TEG-PM and 39% at VerifyNow
This condition is primary fibrinolysis and is identified with the TEG analyzer by an LY30 value of greater than 7
5 Oral anticoagulants, including warfarin and the Although clopidogrel is the most commonly used oral P2Y 12 inhibitor, it is characterized by impaired platelet inhibitory effects in a considerable number of patients
Each of these various tests has limitations, and many require significant Background Traumatic intracranial hemorrhages expand in one third of cases, and antiplatelet medications may exacerbate hematoma expansion
Ticagrelor rapidly achieved greater platelet inhibition than Abstract
Some drugs work together, complementing or backing up each other
TPM is a modification of the TEG assay that isolates platelet function in the clotting process and allows for the comparison of the maximal amplitude (MA) value, under four different
Thromboelastography (TEG) 5
Whereas clopidogrel resistance has been viewed as the occurrence of an adverse cardiovascular event while a patient is on clopidogrel therapy, the most acceptable definition of resistance/nonresponsiveness to an antiplatelet agent is the failure of the drug to inhibit its target of action ()
Flaminio and Pasquale De Vico and Valentina Ajello and Luigi Chiariello