It was originally theorized that the
6% for those with reported penicillin allergy and 47
In our case series cross-reactivity or co-reactivity commonly occurred among the beta-lactam antibiotic class, however further research is required to
Stevens-Johnson syndrome (SJS) toxic epidermal necrolysis (TEN) drug rash with eosinophilia & systemic Cross-reactivity among beta-lactam antibiotics with similar or identical side chains has been documented
Knowing the sensitizing potential of penicillin, topical use is now widely avoided
Issues of cross-reactivity between cephalosporins, penicillins, and related drugs, and the subsequent use of cephalosporins and related antibiotics in patients with cephalosporin or penicillin allergy, are discussed Cross-reactivity is possible through the core β-lactam ring, adjacent thiazolidine (penicillin) or dihydrothiazine (cephalosporin) ring, and also from a side chain, R1, or R2 group (left panel)
This has implications for any kind of test or assay, including diagnostic tests in medicine, and can be a cause of false positives
Cephalosporins have both an R 1 and R 2 group and penicillins only an R 1
Mislabeling patients with penicillin allergy can lead to a higher utilization of second line antimicrobial agents, potentially increasing costs and resistance due to a larger spectrum of activity
Skin eruptions may occur in 1
" Instead, cross-allergic reactions are restricted to much smaller groups of antibiotics that share greater structural similarity
23,25-27 At the antibiotic A total of 9
Patients with cephalosporin allergy appear to be at higher risk for a reaction to other beta-lactam antibiotics because of shared chemical structures (beta-lactam ring, R group side chains)
IgE-mediated allergic reactions with cross-reactivity between vancomycin and teicoplanin have been documented